The Syracuse Orange Football begins the 2021 season on Labor Day weekend on Sept. 4, at Ohio Peden Stadium, Athens available on CBS Sports Network.
Syracuse hosts Rutgers on September 11 followed by Albany, Liberty on September 24 and travels to Florida State on Saturday, October 2.
Syracuse Orange’s 2021 Football Schedule
| Date | Matchup | Venue | Network |
| Saturday, September 4, 7:00 PM | @ Ohio | Peden Stadium, Athens, OH | CBS |
| Saturday, September 11, 2.00 PM | vs. Rutgers | Carrier Dome, Syracuse, NY | ACCN |
| Sunday September 18, 12.00 PM | vs. Albany | Carrier Dome, Syracuse, NY | ESPN |
| Friday, September 24, 8.00 PM | vs. Liberty | Carrier Dome, Syracuse, NY | TBA |
| Saturday, October 2, TBA | @ Florida State | Doak Campbell Stadium, Tallahassee, FL | TBA |
| Saturday, October 9, TBA | vs. Wake Forest | Carrier Dome, Syracuse, NY | TBA |
| Saturday, October 15, 7 PM | vs. Clemson | Carrier Dome, Syracuse, NY | ESPN |
| Saturday, October 23, TBA | vs. Virginia Tech | Lane Stadium, Blacksburg, VA | TBA |
| Saturday, October 30, TBA | vs. Boston College | Carrier Dome, Syracuse, NY | TBA |
| Saturday, November 13, TBA | @ Louisville | Cardinal Stadium, Louisville, KY | TBA |
| Saturday, November 20, TBA | NC State | Carter-Finley Stadium, Raleigh, NC | TBA |
| Saturday, November 27, TBA | vs. Pittsburgh | Carrier Dome, Syracuse, NY | ESPN |
