ESPN will present at least one game in each week of the regular season since the company began airing the Monday Night Football package in 2006.
ESPN’s 2021 Monday Night Football engagement will feature:
- Grand Opening: The 2021 Monday Night Football campaign begins with an ABC simulcast of ESPN’s production, as the Las Vegas Raiders are expected to welcome fans into Allegiant Stadium on Sept. 13.
- MVPs: The season’s first two weeks feature the 2019 and 2020 NFL MVPs, as Aaron Rodgers and the Packers host the Detroit Lions in Week 2 on Sept. 20, following Lamar Jackson and the Ravens’ trip to Vegas. Jackson and the Ravens return to host the Colts in Week 5 on Oct. 11.
- Star Power: Tom Brady and Patrick Mahomes, the two most recent Super Bowl MVPs, each appear on the schedule, with both hosting the New York Giants – Buccaneers in Week 11 on Nov. 22 and Chiefs in Week 8 on Nov. 1.
- Ben Roethlisberger and Russell Wilson will appear twice – the Steelers host the Bears in Week 9 on Nov. 8 and the Browns for Week 17 on Jan. 3, and the Seahawks host the Saints in Week 7 on Oct. 25 and travel to Washington in Week 12 on Nov. 29.
- Talking Playoffs: All 14 teams that qualified for the 2020 NFL Playoffs are set to appear on the MNF schedule, including half of the playoff teams appearing multiple times.
- Divisional Matchups: Eight Monday Night Football matchups feature divisional contests, including Philadelphia at Dallas in Week 3 on Sept. 27, both the Eagles and Cowboys first NFC East game of the season. In the middle of the season, Matthew Stafford and the Rams travel to San Francisco in Week 10 on Nov. 15. Monday Night Football then concludes the season with divisional matchups in four of its last five weeks, including the 140th all-time matchup between the Browns and Steelers on Jan.3.
- Leaders of the Pack: Three showdowns of teams that each won their division last year: Buffalo at Tennessee in Week 6 on Oct. 18, New Orleans at Seattle in Week 7 on Oct. 25, and Seattle at Washington in Week 12 on Nov. 29.
- Emerging Stars: 2020 NFL Offensive Rookie of the Year Justin Herbert makes his home Monday Night Football debut when the Chargers host the Raiders in Week 4 on Oct. 4. Josh Allen, last year’s Fantasy Football Player of the Year, also appears twice – at Tennessee in Week 6 onOct. 18 and hosting New England in Week 13 on Dec. 6.
- Kyler Murray also makes his home Monday Night Football premiere against the Rams in Week 14 on Dec. 13 before Tua Tagovailoa makes his first Monday Night Football appearance in New Orleans in Week 16 on Dec. 27.
ESPN’s broadcast Schedule Of 2021 NFL Regular Season Schedule:
| NFL Week | Date & Time (ET) | Game | Network(s) |
| Preseason | Fri, Aug 20, 8 PM | Kansas City at Arizona | ESPN |
| Preseason | Mon, Aug 23, 8 PM | Jacksonville at New Orleans | ESPN |
| 1 | Sep 13, 8:15 PM | Baltimore at Las Vegas | ESPN, ABC, ESPN Deportes |
| 2 | Sep 20, 8:15 PM | Detroit at Green Bay | ESPN, ESPN Deportes |
| 3 | Sep 27, 8:15 PM | Philadelphia at Dallas | ESPN, ESPN Deportes |
| 4 | Oct 4, 8:15 PM | Las Vegas at Los Angeles Chargers | ESPN, ESPN Deportes |
| 5 | Oct 11, 8:15 PM | Indianapolis at Baltimore | ESPN, ESPN Deportes |
| 6 | Oct 18, 8:15 PM | Buffalo at Tennessee | ESPN, ESPN Deportes |
| 7 | Oct 25, 8:15 PM | New Orleans at Seattle | ESPN, ESPN Deportes |
| 8 | Nov 1, 8:15 PM | NY Giants at Kansas City | ESPN, ESPN Deportes |
| 9 | Nov 8, 8:15 PM | Chicago at Pittsburgh | ESPN, ESPN Deportes |
| 10 | Nov 15, 8:15 PM | Los Angeles Rams at San Francisco | ESPN, ESPN Deportes |
| 11 | Nov 22, 8:15 PM | New York Giants at Tampa Bay Buccaneers | ESPN, ESPN Deportes |
| 12 | Nov 29, 8:15 PM | Seattle at Washington Football Team | ESPN, ESPN Deportes |
| 13 | Dec 6, 8:15 PM | New England at Buffalo | ESPN, ESPN Deportes |
| 14 | Dec 13, 8:15 PM | Los Angeles Rams at Arizona | ESPN, ESPN Deportes |
| 15 | Dec 20, 8:15 PM | Minnesota at Chicago | ESPN, ESPN Deportes |
| 16 | Dec 27, 8:15 PM | Miami at New Orleans | ESPN, ESPN Deportes |
| 17 | Jan 3, 8:15 PM | Cleveland at Pittsburgh | ESPN, ESPN Deportes |
| 18 | Sat, Jan 8, 4:15 PM | TBD | ESPN and ABC, ESPN Deportes |
| 8:15 PM | TBD | ESPN, ABC, ESPN Deportes | |
| NFL Wild Card | TBD | TBD | ESPN, ABC, ESPN Deportes |
| Pro Bowl | Sunday, Feb. 6, 3 PM | AFC vs. NFC (Las Vegas) | ESPN, ABC, ESPN Deportes |
